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Low Solubility Solutions

UPM Pharmaceuticals Low Solubility Solutions HME-150-ppiLow Solubility Solutions : Providing for R&D development and cGMP manufacture of solid dosage forms containing poorly soluble APIs. UPM realizes that many clients do not want the added expense of proprietary technologies or comprehensive fixed price programs. UPM first analyses a matrix of scientific principles that focus the development path most suitable for the API. In this way, the Client gets the benefit of a strategic scientific based, customized plan that is cost effective too.

Recognizing that about 75% of NCEs are classified as low solubility compounds, UPM has made a major capital commitment to enhance its services to formulate these compounds. Along with our outstanding research and development team, we will now be able to help our clients with formulation development in this challenging field of poorly soluble APIs.

Equipment Highlights:

UPM Pharmaceuticals Low Solubility Solutions buchi spray dryerFPS Pilot Mill-2 Jet Mill

  • Can process down between 0.5 and 20 µm particles
  • For batches from 1 g to 3 kg

IK – A IKA Labor – Pilot 2000/4

  • Can process down between 5 – 20 µm
  • Six modules for stirring, homogenizing, emulsifying, and wet milling

Micro DeBEE Homogenizer

  • Maximum continuous flow rate of 250 ml per minute
  • Pressure continuously adjustable from 2,000 to 30,000psi

Buchi Spray Dryer B-290

  • Can process down between 0.5 to 25 µm particles
  • Evaporative capacity of 1.0 liter per hour of water, higher for solvents

Silverson Model L5M-A Mixer Homogenizer

  • 1 ml to 12 liter capacity, In-line assembly can process approximately 20 liter per minute
  • Suitable for mixing, emulsifying, disintegrating and dissolving

Leistritz Nano-16 Twin Screw Hot Melt Extrude

  • 30 g batches up to 1 kg per hour for Nano-16
  • Up to 3 kg. per hour for Micro-18 configuration using dual twin-screw gravimetric feeders
  • Micro Liquid Additive Injection System (0.2-10 ml/min)

Click Here to read:   Hot Melt Extrusion – Meeting the Solubility Challenge

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